Primary Bone Cancer

Two most common types of bone cancer are 1) multiple myeloma and 2) Ewing's sarcoma.

1) Multiple Myeloma is a neoplasm of bone marrow that decreases marrow and osseous tissue formation. It also affects plasma cell development.
S&S: insidious onset (usually asymptomatic in early stage); pain, fx (flat bones such as ribs), hypercalcemia, and deformities; pt may present with immunocompromised signs secondary to abnl plasma cell formation; middle aged & elderly pt.

2) Ewing's sarcoma - also a tumor of bone marrow.
S&S: pain, swelling, fevor, leukocytosis; actual tumor cell may be difficult to differentiate from the surround tissue upon surgical exploration.
cf. to the multiple myeloma it affects long bones and pelvis commonly and found in adolescence specially boys.

3) Another form of bone cancer often closely related to the lymphoma.
mainly, lymphoma take in two forms: Hodgkin's and Non-Hodgkin's (NHL). The third form of lymphoma is rare in northern America. All types have different level of tissue involvement, but manifestations are all similar - lymphoid enlargement, wkness, fever, wt. loss, and anemia.

Hodgkin's type often found in young adults and respond to tx well; while NHL affects middle-aged pts and difficult to tx.